| Abstract: |
Introduction
Acoustic radiation contrast (ARC) in MR phase images is a recently developed method to image and quantify non-invasively the viscoelastic properties in vivo [1,2]. It is well known that tissue elastic properties may be altered by tumors. Young's modulus of breast tumors may differ from surrounding tissues by a factor of 90-fold. The ARC-MR images may be helpful in the distinction of benign from malignant masses. To test the applicability and feasibility of ARC-MR, a commercially available breast phantom was investigated and finite-element simulations were performed. Combining measurements and finite-element simulations yields the elastic and acoustic parameters of the phantom.
Methods and Materials
Ultrasound (US) waves with a center frequency of 2.5 MHz were coupled into the breast phantom with the focal plane inside it. The acoustic radiation force leads to a displacement of the material inside its path in beam propagation direction. The displacement can be calculated from the phase shift in the phase images according to [2]. It was measured using a modified spin-echo sequence with monopolar gradients added for displacement encoding (sequence parameters: TE/TR: 60/400 ms, monopolar gradient length and amplitude: 20 ms and 20 mT/m, voxel: 1.7x1.7x3 mm3). The 20 ms US pulse was irradiated simultaneously with the second gradient pulse using external triggering. Intensities of 35 W/cm2 were used and provided by a home-built MR-compatible piezoelectric transducer. The transducer had a diameter of 5 cm and a focal length of 22 cm. The phase images were acquired at a 1.5 T Magnetom Avanto scanner (Siemens Healthcare, Erlangen (Germany)) with a 4 channel breast coil (NORAS MRI products GmbH, Höchberg (Germany)). The breast elastography phantom (CIRS, Norfolk, Virginia (USA)) accurately mimics the ultrasonic characteristics of tissues found in an average human breast. The lesions are three times stiffer than the background so they can be detected on elastograms [4]. A lesion of 0.9 cm diameter was investigated. For the finite-element simulations (Marc Mentat, MSC Software Corporation, Santa Ana, CA (USA)) the parameters were adjusted to fit the measurements: US beam diameter: 0.4 cm, US pulse length: 20 ms, US intensity: 35 W/cm2; geometry: cylinder with diameter: 4 cm, length: 6,4 cm; material parameters: elastic moduli: 10 kPa for the breast tissue [5] and 30 kPa for the lesion, Poisson's ratio: 0.495, density: 1 g/cm3, absorption coefficient: 0.345 cm-1.
Results
Figure 1 a) & b) show a T2-weighted amplitude image and a phase image of the breast phantom in sagittal plane without US; direction of displacement detection: A |
, M. Radicke