MR-rheology: visualisation of the viscoelastic properties of the human brain

proband in the MRI system

The knowledge of viscoelastic parameters of the human brain may help in medical diagnostics, e.g. dementia,  hydrocephalus, brain cancer, and multiple sclerosis. We develop a novel method of in vivo visualisation of elastic properties of the human brain inspired by well known techniques in material science.

To perform a measurement of these properties, the head is fixated on a self-made lifting device inside an MRI head coil and lifted a small distance. The head is then dropped in a controlled motion synchronized to the imaging sequence. An abrupt motion of the cranial bone should cause a delayed motion (creeping) of the brain tissue. The velocity of this motion and the time required to reach the steady state are dependent on the spring and damping constants.

Magnitude image
Phase image without motion
Phase image with motion